Tony, no single 'fix' is going to completely secure your WordPress installation. There are many fronts on which WordPress (or any other online software platform for that matter) can be attacked and there are people who spend their waking hours seeking out those flaws.

The goal is to develop a security consciousness and to add security measures when they are available. Also upgrading as soon as possible when a new version is released.

The goal here is to make it more difficult, by removing the easy stuff and the commonly known stuff. Most WordPress blogs are hacked by script kiddies who read about vulnerabilities after the fact and then use automated tools to hack them. The guys who actually find and write the attacks are typically not interested in everyday average blogs.